The use of Depo-Provera for these women may be particularly concerning.ĭepo-Provera can be an effective medication for birth control and reducing symptoms associated with having periods. In some autoimmune situations, increased (abnormal) blood clotting is a problem. People with DS are thought to have a higher incidence of autoimmune conditions such as autoimmune thyroid disease, Rheumatoid arthritis, and others. This seems to be on the basis of autoimmune conditions (the body's immune system being directed at a component of the body). We have found a number of our patients with a predisposition to abnormal clotting. We may reduce cyclic mood changes but increase overall depression or mood problems.ĭepo-Provera can increase the risk of abnormal blood clotting. We have found this to be a problem, for example, in a woman we are trying to reduce mood swings associated with the menstrual cycle. Particularly in the first year of use, the periods (or spotting/bleeding) may be less predictable and more frequent and this can reduce the benefit of trying to reduce the periods (at least in the first year).ĭepo-Provera can contribute to mood changes or depression. There are some particular issues that we consider for our female patients with Down syndrome such as:ĭepo-Provera does require an injection every 3 months which some of our patients find challenging.ĭepo-Provera can increase osteoporosis (thinning of the bones) which is already more common in people with DS. (Pfizer, the manufacturer of the drug, produced a handout that you can find at this link. It doesn't protect against sexually transmitted diseases. Since periods often are stopped altogether while using Depo-Provera, it can be helpful for those women who are challenged by managing their periods (which can be an issue for some women with Down syndrome). It is an effective form of birth control and, when it eliminates periods completely, it can be an effective way to eliminate symptoms associated with periods. Many women will stop having their menses (periods) when receiving the Depo-Provera injection regularly (menses will resume when the shot is no longer used). Reduce periods and/or symptoms from periods We received a question about the use of Depo-Provera.ĭepo-Provera is an injection of progesterone that is used to:
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